Age, sex, comorbidities, outpatient medication, oxygen saturation on hospital admission, and the duration of the current episode of AECOPD of the patients requiring ICU treatment did not differ significantly from the overall patient cohort. In univariate Cox regression analysis BNP, accurately predicted the need for ICU care (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.03 to 1.22 for an increase in BNP of 100 pg/mL; p = 0.009). This strong association persisted in multivariate analysis (HR, 1.13; 95% CI, 1.03 to 124 for an increase in BNP of 100 pg/mL; p = 0.008) [Table 2]. To the contrary, BNP levels did not differ significantly between survivors and in-hospital nonsurvivors (64 pg/mL [IQR, 32 to 195 pg/mL] vs 81 pg/mL [IQR, 57 to 1,103]; p = 0.362).
BNP Levels as Prognostic Marker for Medium- and Long-term Mortality
Overall, 16 patients (7%) died during the 6-month follow-up period and 46 patients (22%) died within 2 years of the initial hospitalization. AECOPD (16 patients), cardiac death (7 patients), and pneumonia (6 patients) were the most common causes of death. BNP levels on presentation did not differ significantly between nonsurvivors and survivors after 6 months of follow-up (67.3 pg/mL [IQR, 49.5 to 184.9] vs 63.5.7 pg/mL [IQR, 31.7 to 194.5];p = 0.610).
Table 2—Prediction of the Need for ICU Treatment with Viagra Australia in Univariate and Multivariate Regression Analysis
| HR | p | |
| Predictors | (95% CI) | Value |
Univariate analysis
| Age | 0.988 (0.937-1.042) | 0.651 |
| Anthonisen class | 1.643 (0.978-2.761) | 0.061 |
| BNP, for an increase | 1.118(1.029-1.215) | 0.009 |
| of 100 pg/mL | ||
| CRP | 1.005 (0.995-1.015) | 0.334 |
| GOLD class | 0.826 (0.496-1.376) | 0.436 |
| Left ventricular | 0.974 (0.947-1.002) | 0.068 |
| ejection fraction Cheap viagra online | ||
| Paco2 on hospital | 1.038(1.001-1.077) | 0.042 |
| admission | ||
| Procalcitonin | 1.080 (0.734-1.588) | 0.696 |
| Pulmonary arterial | 1.011 (0.964-1.061) | 0.646 |
| pressure | ||
| Serum pH mexican online pharmacy | 0.001 (0.000-0.438) | 0.026 |
| Multivariate analysis | ||
| BNP, for an increase | 1.133 (1.033-1.242) | 0.008 |
| of 100 pg/mL | ||
| Paco2 on hospital | 1.069 (1.007-1.134) | 0.029 |
| admission | ||
| Serum pH | 16.449 (0.01-217918) | 0.563 |